Hmmm... Two months and no reply. Doesn't look good. I played it fine on one computer, but when I got a new computer the game won't run for me either. I got a gray rectangle with the title "Saints Row: The Launcher" that I could move around. I tried all the verify integrity and uninstall and delete local files and reinstall and they didn't help. The rectangle is smaller than the DX9/10 or DX11 selector window I got on my other computer, and I can move it around with the moust and close it by hitting ESC, but no other keys or mouse clicks seem to do anything. I completely reinstalled windows and still no good. I tried various compatibility settings, still no good. I'm running Win 7 64 bit professional and have a 560 Ti video card with 2MB FYI.
One thing I noticed is that before reinstalling windows, running the saintsrowthethird.exe and saintsrowthethird_dx11.exe seemed to quit and run the launcher. After all of this for some reason I can now run the direct exes and get the first two movies, then a window saying "Saints Row: the Third has stopped working".